Prevalence of Allelic and Genotypic Variants of Il4, Il10, Il12b and Tlr2 Gene Polymorphism in Patients with Chronic Polypoid Rhinosinusitis
Djuraev Jamolbek Abdukhakhorovich, Doctor of Philosophy (PhD), Senior Teacher, Department of Otolaryngology and stomatology of Tashkent Medical Academy, Republic of Uzbekistan.
Manuscript received on 21 July 2021 | Revised Manuscript received on 10 August 2021 | Manuscript Accepted on 15 August 2021 | Manuscript published on 30 August 2021 | PP: 11-19 | Volume-1 Issue-2, August 2021 | Retrieval Number: 100.1/ijadst.B1004081221 | DOI: 10.54105/ijadst.B1004.081221
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Abstract: Chronic polyposis rhinosinusitis (CPRS) is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Bronchopulmonary, rhinogenic orbital and intracranial complications arising against the background of chronic sinusitis not only worsen the quality of life of patients, but also sometimes lead to long-term disability, and sometimes to disability. The results of our study demonstrated that the distribution of the genotypes of polymorphisms of all genes corresponded to the expected, i.e., in this case, the Hardy-Weinberg equilibrium is fulfilled in both groups. Both samples rs2243250 of the IL4 gene were characterized by high frequencies of the unfavorable C allele and the heterozygous T / C genotype, rs3212227 of the IL12B gene of the A allele and the heterozygous A / C genotype, rs1800895 592 C> A in the IL10 gene of the A, C alleles, and heterozygous C rs5743708 in the TLR2 gene of the C allele and the heterozygous C / T genotype, hence the high level of genetic variability of the studied genes.
Keywords: Polyps, Nose, Polymorphism, Gene, Locus, Allele.
Scope of the Article: Polymorphism