Volume-1 Issue-2, August 2021 – International Journal of Advanced Dental Sciences and Technology (IJADST)

B1004081221

IJADST Journal — Mon, 09 Aug 2021 05:43:26 +0000

The International Journal of Advanced Dental Sciences and Technology (IJADST) has ISSN 2582-757X (online) which is an online, open access, peer reviewed periodical bi-monthly international journal. This journal is published by Lattice Science Publication (LSP) in the months of February, April, June, August, October and December. The aim of the journal is to publish high quality peer–reviewed original articles in the area of Dental Sciences that covers Community Dentistry, Conservative Dentistry and Endodontics, Oral and Maxillofacial Surgery, Oral Medicine and Radiology, Oral Pathology, Orthodontics and Dentofacial, Orthopaedics, Paedodontics, Periodontics and Prosthodontics, Physiology, Physiology, Human Oral Anatomy, Physiology, Tooth Morphology, Oral Microbiology, Oral and Maxillofacial Surgery. Author (s) can submit articles electronically round the year. The Editors reserve the right to reject articles without sending them out for review. Submitted articles should not have been previously published or be currently under consideration for publication elsewhere. Briefs and research notes are not published in this journal. Submitted articles must be within the scope of the journal. All articles go through a double-blind peer review policy. After the final acceptance of the article, based upon the detailed review process and submission of required documents, the article will publish online immediately. However, the assignment of the article of specific issue (see archive) will be taken up by the editors later; and the author will be intimated accordingly. For theme based special issues, time bound special calls for articles will be announced. #Community Dentistry #Conservative Dentistry and Endodontics #Oral and Maxillofacial Surgery #Oral Medicine and Radiology #Oral Pathology #Orthodontics and Dentofacial #Orthopaedics #Paedodontics #Periodontics and Prosthodontics #Physiology #Human Oral Anatomy Physiology #Tooth Morphology #Oral Microbiology #Oral and Maxillofacial Surgery #PhD #Academic #Scopus #SCI #LatticeScience #Springer, #ScienceDirect #IEEE #Mendeley #Research #Scholarship #UGC #SSRN #LatticeScience #ESCI #Science #Journal #Conference #SSRN #PubLons

Prevalence of Allelic and Genotypic Variants of Il4, Il10, Il12b and Tlr2 Gene Polymorphism in Patients with Chronic Polypoid Rhinosinusitis
J.A. Djuraev

Djuraev Jamolbek Abdukhakhorovich, Doctor of Philosophy (PhD), Senior Teacher, Department of Otolaryngology and stomatology of Tashkent Medical Academy, Republic of Uzbekistan.

Open Access | Ethics and Policies | Cite | Mendeley | Indexing and Abstracting
© The Authors. Published by Lattice Science Publication (LSP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: Chronic polyposis rhinosinusitis (CPRS) is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Bronchopulmonary, rhinogenic orbital and intracranial complications arising against the background of chronic sinusitis not only worsen the quality of life of patients, but also sometimes lead to long-term disability, and sometimes to disability. The results of our study demonstrated that the distribution of the genotypes of polymorphisms of all genes corresponded to the expected, i.e., in this case, the Hardy-Weinberg equilibrium is fulfilled in both groups. Both samples rs2243250 of the IL4 gene were characterized by high frequencies of the unfavorable C allele and the heterozygous T / C genotype, rs3212227 of the IL12B gene of the A allele and the heterozygous A / C genotype, rs1800895 592 C> A in the IL10 gene of the A, C alleles, and heterozygous C rs5743708 in the TLR2 gene of the C allele and the heterozygous C / T genotype, hence the high level of genetic variability of the studied genes.

Keywords: Polyps, Nose, Polymorphism, Gene, Locus, Allele.
Scope of the Article: Polymorphism

Download PDF

The post B1004081221 appeared first on International Journal of Advanced Dental Sciences and Technology (IJADST).

B1003081221

IJADST Journal — Mon, 09 Aug 2021 04:30:05 +0000

Results of Frequency Analysis Distribution of A1188c Rs3212227 Polymorphism in the IL12b Gene among Patients with Chronic Polypoid Rhinosinusitis
J.A. Djuraev¹, U. S. Khasanov²

¹Khasanov Ulugbek Saidakramovich, Doctor of Science, Professor, Department of Otolaryngology and stomatology of Tashkent Medical Academy, Republic of Uzbekistan.

²Djuraev Jamolbek Abdukhakhorovich, Doctor of Philosophy (PhD), Senior Teacher, Department of Otolaryngology and stomatology of Tashkent Medical Academy, Republic of Uzbekistan.

Abstract: Our data confirm the complexity of the genetic mechanism for the development of polyposis processes in patients with CPRS and indicate the necessity and importance of understanding complex gene interactions in the analysis of the development and clinical stage of the studied pathology. Material and methods. In accordance with the purpose of the study and to fulfill the assigned tasks, clinical studies were carried out in 140 patients with CPRS and with chronic rhinosinusitis, who were examined and treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in 2017-2019. To study the diallelic polymorphism of the promoter regions of the genes of the studied interleukins, 50 healthy (no CPRS) donors, men and women, were examined. The average age of the examined donors was 51.3 ± 1.44 years. Conclusion. Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C / C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. The study of the distribution of genotypes showed that the homozygous genotype A / A was insignificant, almost 1.2 times more often found in group 1 (80.64%), while the frequency of detection of the heterozygous genotype A / C was insignificantly 1.1 times higher among patients with HRC 2 groups. The opposite situation could be observed in the study of the homozygous C / C genotype, which was not identified among all study groups.

Keywords: Polymorphism, Gene, Genotypes, Polyposis Processes, Allele.
Scope of the Article: Polymorphism

Download PDF

The post B1003081221 appeared first on International Journal of Advanced Dental Sciences and Technology (IJADST).

B1002081221

IJADST Journal — Mon, 09 Aug 2021 04:21:14 +0000

Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy
U.S.Khasanov¹, S.S.Sharipov²

¹Khasanov Ulugbek Saidakramovich, Doctor of Science, Professor, Department of Otolaryngology and stomatology of Tashkent Medical Academy, Republic of Uzbekistan.

²Sharipov Sanjar Salomovich, Doctor of philosophy (PhD), Associate Professor, Department of Otorhinolaryngology of Tashkent State Dental Institute, Republic of Uzbekistan.

Open Access | Ethics and Policies | Cite | Mendeley | Indexing and Abstracting
© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: It is interesting to note that the adverse effect of this genotype was observed exclusively in patients with ronchopathy, while in patients with ronchopathy, the frequency of this genotype did not differ in comparison with the control group, i.e. there is a significant tendency to an increase in the genotype with an increase in the severity of the pathology. Material and methods. To solve the set tasks, 208 patients with various diseases of the upper respiratory tract, with nasal breathing disorders, causing ronchopathy, who were hospitalized in the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy for 2015 to 2021, were examined. The control group consisted of 50 apparently healthy people who agreed to participate in the study (students, masters, clinical residents). Among the sick men there were 144 (73%), women – 64 (27%). The age of the patients ranged from 18 to 70 years, averaging 44.5 ± 6.8 years. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC Hematology. This part of the work consisted of several stages: 1. Blood sampling. 2. Isolation of DNA from peripheral blood lymphocytes. 3. Carrying out PCR. 4. Conducting electrophoresis and visualizing the results (if necessary). The analysis of the TGFb1 gene polymorphism associations was carried out using a case-control model (case-control, comparison of two samples). The sample “case” was formed from 104 patients with ronchopathy. Conclusion. Since this work is one of the few works on the study of the relationship between rs 2010963 of the VEGFA gene and the risk of developing ronchopathy, our data may become the subject of further discussions.

Keywords: Ronchopathy, Allele, Genotype, Polymorphism, Gene.
Scope of the Article: Oral Pathology

Download PDF

The post B1002081221 appeared first on International Journal of Advanced Dental Sciences and Technology (IJADST).